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Epidemio-Clinical and Paraclinical Aspects of Venous Thromboembolic Diseases in a Cardiology Department in Mali

Received: 6 May 2024     Accepted: 21 May 2024     Published: 30 May 2024
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Abstract

Introduction: Venous thromboembolic diseases (VTED) include deep vein thrombosis of the lower limbs and pulmonary embolism (PE), which is its severe form due to its high mortality. The objective of our study was to determine the epidemio-clinical and paraclinical aspects of patients hospitalized for venous thromboembolic diseases. Patients and method: Cross-sectional study with prospective recruitment from patient records hospitalized for (VTED) from January to December 2023 in the cardiology department of the Mother-Child University Hospital in Bamako, Luxembourg. Results: We collected 55 out of 580 patient records hospitalized for (VTED), a hospital frequency of 9.48%. PE accounted for 58.20% of cases, 10.90% for deep vein thrombosis (DVT), and 30.90% for their association. The mean age of patients was 55.56 years ± 15.52 years. The majority of patients, 90%, were under 66 years of age. The predominance was female, 56%. In lower extremity DVT, calf pain and Homans' sign were present in 56% and 24% of patients. In pulmonary embolism, dyspnea and chest pain were present in 85.50% and 65.50% of patients. Etiological factors were dominated by neoplasia in 10.90%, contraception 5.45% and orthopedic surgery in 5.45% of cases. Cardiovascular risk factors were a sedentary lifestyle (50.90%), obesity (34.45%), high blood pressure (36.36%) and diabetes (21.81%). Laboratory abnormalities were elevation of troponin (46.87%), BNP (40.62%), D-Dimer (62.50%) and anemia (9.09%). Electrocardiographic abnormalities were tachycardia in 65.4% and S1Q3 in 21.81% of patients. Echocardiography showed dilation of the right cavities (47.27%), systolic pulmonary arterial hypertension (38.18%) and thrombus in the right cavitary (5.45%). On thoracic CT angiography, PE was proximal (36.40%), bilateral (61.80%) and massive (29.10%). On venous Doppler ultrasound, TVP was proximal in 65.21%. Conclusion: VETD was more common in women and younger subjects.

Published in Cardiology and Cardiovascular Research (Volume 8, Issue 2)
DOI 10.11648/j.ccr.20240802.14
Page(s) 73-77
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This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Thromboembolic Diseases, Epidemiology, Clinical, Paraclinical, Mali

1. Introduction
Venous thromboembolic disease (VTED) includes deep vein thrombosis of the lower extremity and pulmonary embolism . Venous thromboembolic disease is a serious disease with significant morbidity and mortality. In 2004, 370,000 deaths were attributed to VTE in 6 European countries . In sub-Saharan Africa, they are underdiagnosed because of clinical polymorphism, hence the initiative of this work, which is set as an objective.
2. Patients and Method
This is a cross-sectional study with prospective recruitment over a period of one year, from January to December 2023, carried out in the cardiology department of the Mother-Child University Hospital in Bamako, Luxembourg. All patients of both sexes and of all ages hospitalized in the VTE department confirmed by CT angiography of the pulmonary arteries and/or venous Doppler ultrasound of the lower extremities were included. Information was collected for each patient on a card. The diagnosis of VTE was based on clinical evidence, Wells Clinical Probability (DVT) and Revised Geneva (EP) Clinical Probability Scores, and data from venous lower extremity Doppler ultrasound and CT angiography of the pulmonary arteries. Sociodemographic characteristics of patients, etiological factors of VTE (cancer, recent surgery, especially orthopedic surgery, contraception, prolonged bed rest, postpartum), cardiovascular risk factors (hypertension, diabetes, smoking, dyslipidemia, obesity, sedentary lifestyle, heredity) were sought. Data were entered on Word 2016 and Excel 2007 and analyzed on SPSS version 22. Confidentiality was respected and data processing was anonymous.
3. Results
We collected 55 out of 580 patient records hospitalized for VTE, i.e. a hospital frequency of 9.48%. PE accounted for 58.20% of cases, 10.90% for DVT, and 30.90% for their association (Figure 1). The mean age of patients was 55.56 years ± 15.52 years. The majority of patients, 90%, were under 66 years of age. The predominance was female, 56%. In lower extremity DVT, calf pain and Homans' sign were present in 56% and 24% of patients. In pulmonary embolism, dyspnea and chest pain were present in 85.50% and 65.50% of patients. Etiological factors were dominated by neoplasia in 10.90%, contraception 5.45% and orthopedic surgery in 5.45% of cases. Cardiovascular risk factors were physical inactivity (50.90%), obesity (34.45%), hypertension (36.36%) and diabetes (21.81%) (Table 1). Laboratory abnormalities were elevation of troponin (46.87%), BNP (40.62%), D-Dimer (62.50%) and anemia (9.09%). Electrocardiographic abnormalities were tachycardia in 65.4% and S1Q3 in 21.81% of patients. Echocardiography showed dilation of the right cavities (47.27%), systolic pulmonary arterial hypertension (38.18%) and thrombus in the right Right cavitary (5.45%). On thoracic CT angiography, PE was proximal (36.40%), bilateral (61.80%) and massive (29.10%). On venous Doppler ultrasound, DVT was proximal in 65.21% (Table 2).
Table 1. CV risk factors and etiological Factors.

CV risk factor and Etiological Factors

Number

%

High blood pressure

20

36,36

Diabetes

12

21,81

Dyslipidemia

4

7,27

TOBACCO

7

12,72

Obesity

19

34,45

Sedentary lifestyle

28

50,90

History of DVT

2

3,63

History of PE

4

7,27

CANCER

6

10,90

Pregnancy or postpartum

2

3,63

Contraception

3

5,45

Orthopedic surgery

3

5,45

Table II: Paraclinical data

Table 2. CV risk factor and Etiological Factors of VTE.

Para-clinical data

Number

%

Biology n = 32

D-Dimer

20

62,50

Troponins

15

46,87

NPP

13

40,62

ECG n=55

Tachycardia

36

65,45

S1Q3

12

21,81

BBD

3

5,45

FA

1

1,81

Negative T Waves V1-V4

4

7,27

Cardiac Doppler Echo n= 55

Right-hand cavity expansion

26

47,27

PAH

21

38,18

Intracavitary thrombus

3

5,45

VCI Expansion

6

10,90

Venous Doppler ultrasound n=23

Proximal DVT

15

65,21

Distal DVT

8

34,78

CT angiography of pulmonary arteries n= 30

Proximal PE

17

56,66

Distal PE

19

43,33

Unilateral PE

11

36,66

Bilateral PE

19

63,33

Massive PE

8

26,66

4. Discussion
The hospital frequency of VTED in the study was 9.48%, close to Damorou's 9.1% , higher than Owono's 1.6% , Igun's 3.80% , and Coulibaly's 4.95% , but lower than Thiam's 26% . The distribution of VTED was 58.20% isolated pulmonary embolism, 10.90% isolated deep vein thrombosis and their association of 30.90%, the same observation made by Coulibaly and Thiam in disagreement with Mbaye , Nourelhouda and Simeni who found the predominance of DVT with 66.7% and 49.5% respectively. The mean age of our patients was 52.9 ± 16.4 years with extremes of 29 and 80 years in agreement with the literature .
The predominance was female, superimposed on the rest of the literature . The cardiovascular risk factors found were a sedentary lifestyle (50.90%), obesity (50.90%), high blood pressure (36.36%) and diabetes (21.81%) in agreement with Owono and Ondze-Kafata , while Diall found in his series arterial hypertension and heart disease . For Diedhiou , it was mainly heart failure. The classic etiological factors of VTED were cancer (10.90%), orthopedic surgery (5.45%) and contraception (5,45%). In his series Camara , found 5.6% cancer and 24.1% recent surgery. For Coulibaly , cancer was 16.10% and recent surgery 11.50%. Functional signs in pulmonary embolism were dominated by dyspnea (85.50%) and chest pain (65.50%) in agreement with Damorou . which found 98% and 78.4% respectively. For lower extremity DVT, the clinic was dominated by calf pain (56%) and a positive Homans sign (24%), in agreement with Diedhiou . In our study, the biological abnormalities were elevation of troponin (46.87%), BNP (40.62%), D-Dimer (62.50%) and anemia (9.09%). Coulibaly in his series found an elevation of D-Dimer (100%) of patients and anemia (34.34%). This difference can be explained by the non-systematization of the determination of D-Dimer in our study. Tachycardia (65.45%) and an S1Q3 appearance (21.81%) were the most common electrocardiographic abnormalities in agreement with Camara . On transthoracic echocardiogram and in agreement with Damorou , Coulibaly , right cavitary dilation (47.27%) and PAH (38.18%) were the frequent abnormalities. Venous Doppler ultrasound of the lower limbs found DVT of the lower limbs in 41.81% of cases and it was proximal in the majority of cases (65.21%). In the Camara series of lower extremity DVT was proximal in 56.50% of cases. On CT angiography of the pulmonary arteries, PE was bilateral in 63.33% of cases and proximal in 56.66%s close to MBaye data which found bilateral PE in 74% and proximal in 50% of cases. On the other hand, for Camara , the PE was proximal and distal with 50% each. The embolism was massive in 26.66% of our patients lower than the 33.3% of Camara .
5. Conclusion
Venous thromboembolic diseases are relatively common but underdiagnosed. The predominance was female and affected more subjects under 65 years of age. The classic functional signs were found, namely dyspnea, chest pain and calf pain. The contributing factors were a sedentary lifestyle, obesity and a history of cancer. Proximal and bilateral pulmonary embolism were the most common CT abnormalities and deep vein thrombosis of the lower limbs was proximal in more than half of the cases to venous Doppler of the lower limbs.
6. Limitations of the Study
Single-center study, sample size limit, non-randomization.
Abbreviations

VTED

Venous Thromboembolic Disease

PE

Pulmonary Embolism

DVT

Deep Vein Thrombosis

PAH

Pulmonary Arterial Hypertension

BNP

Brun Natriuretic Peptide

MI

Lower Extremities

BBD

Right Branch Block

IVC

Inferior Vena Cava

Conflicts of Interest
The authors declare no conflicts of interest.
References
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    Mamadou, T., Adiaratou, T. C., Daouda, F., Hamma, S., Mariam, D., et al. (2024). Epidemio-Clinical and Paraclinical Aspects of Venous Thromboembolic Diseases in a Cardiology Department in Mali. Cardiology and Cardiovascular Research, 8(2), 73-77. https://doi.org/10.11648/j.ccr.20240802.14

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    Mamadou, T.; Adiaratou, T. C.; Daouda, F.; Hamma, S.; Mariam, D., et al. Epidemio-Clinical and Paraclinical Aspects of Venous Thromboembolic Diseases in a Cardiology Department in Mali. Cardiol. Cardiovasc. Res. 2024, 8(2), 73-77. doi: 10.11648/j.ccr.20240802.14

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    AMA Style

    Mamadou T, Adiaratou TC, Daouda F, Hamma S, Mariam D, et al. Epidemio-Clinical and Paraclinical Aspects of Venous Thromboembolic Diseases in a Cardiology Department in Mali. Cardiol Cardiovasc Res. 2024;8(2):73-77. doi: 10.11648/j.ccr.20240802.14

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  • @article{10.11648/j.ccr.20240802.14,
      author = {Toure Mamadou and Thiam Coumba Adiaratou and Fofana Daouda and Sankare Hamma and Dagnogo Mariam and Traore Ousmane and Yalcoue Djamila and Guire Sadik Mahamat and Sidibe Samba and Diall Mahan Ameri and Sow Mady and Cisse Almadane and Keita Asmaou and Daffe Sanoussy and Konate Massama and Coulibaly Souleymane and Menta Ichaka},
      title = {Epidemio-Clinical and Paraclinical Aspects of Venous Thromboembolic Diseases in a Cardiology Department in Mali
    },
      journal = {Cardiology and Cardiovascular Research},
      volume = {8},
      number = {2},
      pages = {73-77},
      doi = {10.11648/j.ccr.20240802.14},
      url = {https://doi.org/10.11648/j.ccr.20240802.14},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ccr.20240802.14},
      abstract = {Introduction: Venous thromboembolic diseases (VTED) include deep vein thrombosis of the lower limbs and pulmonary embolism (PE), which is its severe form due to its high mortality. The objective of our study was to determine the epidemio-clinical and paraclinical aspects of patients hospitalized for venous thromboembolic diseases. Patients and method: Cross-sectional study with prospective recruitment from patient records hospitalized for (VTED) from January to December 2023 in the cardiology department of the Mother-Child University Hospital in Bamako, Luxembourg. Results: We collected 55 out of 580 patient records hospitalized for (VTED), a hospital frequency of 9.48%. PE accounted for 58.20% of cases, 10.90% for deep vein thrombosis (DVT), and 30.90% for their association. The mean age of patients was 55.56 years ± 15.52 years. The majority of patients, 90%, were under 66 years of age. The predominance was female, 56%. In lower extremity DVT, calf pain and Homans' sign were present in 56% and 24% of patients. In pulmonary embolism, dyspnea and chest pain were present in 85.50% and 65.50% of patients. Etiological factors were dominated by neoplasia in 10.90%, contraception 5.45% and orthopedic surgery in 5.45% of cases. Cardiovascular risk factors were a sedentary lifestyle (50.90%), obesity (34.45%), high blood pressure (36.36%) and diabetes (21.81%). Laboratory abnormalities were elevation of troponin (46.87%), BNP (40.62%), D-Dimer (62.50%) and anemia (9.09%). Electrocardiographic abnormalities were tachycardia in 65.4% and S1Q3 in 21.81% of patients. Echocardiography showed dilation of the right cavities (47.27%), systolic pulmonary arterial hypertension (38.18%) and thrombus in the right cavitary (5.45%). On thoracic CT angiography, PE was proximal (36.40%), bilateral (61.80%) and massive (29.10%). On venous Doppler ultrasound, TVP was proximal in 65.21%. Conclusion: VETD was more common in women and younger subjects.
    },
     year = {2024}
    }
    

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  • TY  - JOUR
    T1  - Epidemio-Clinical and Paraclinical Aspects of Venous Thromboembolic Diseases in a Cardiology Department in Mali
    
    AU  - Toure Mamadou
    AU  - Thiam Coumba Adiaratou
    AU  - Fofana Daouda
    AU  - Sankare Hamma
    AU  - Dagnogo Mariam
    AU  - Traore Ousmane
    AU  - Yalcoue Djamila
    AU  - Guire Sadik Mahamat
    AU  - Sidibe Samba
    AU  - Diall Mahan Ameri
    AU  - Sow Mady
    AU  - Cisse Almadane
    AU  - Keita Asmaou
    AU  - Daffe Sanoussy
    AU  - Konate Massama
    AU  - Coulibaly Souleymane
    AU  - Menta Ichaka
    Y1  - 2024/05/30
    PY  - 2024
    N1  - https://doi.org/10.11648/j.ccr.20240802.14
    DO  - 10.11648/j.ccr.20240802.14
    T2  - Cardiology and Cardiovascular Research
    JF  - Cardiology and Cardiovascular Research
    JO  - Cardiology and Cardiovascular Research
    SP  - 73
    EP  - 77
    PB  - Science Publishing Group
    SN  - 2578-8914
    UR  - https://doi.org/10.11648/j.ccr.20240802.14
    AB  - Introduction: Venous thromboembolic diseases (VTED) include deep vein thrombosis of the lower limbs and pulmonary embolism (PE), which is its severe form due to its high mortality. The objective of our study was to determine the epidemio-clinical and paraclinical aspects of patients hospitalized for venous thromboembolic diseases. Patients and method: Cross-sectional study with prospective recruitment from patient records hospitalized for (VTED) from January to December 2023 in the cardiology department of the Mother-Child University Hospital in Bamako, Luxembourg. Results: We collected 55 out of 580 patient records hospitalized for (VTED), a hospital frequency of 9.48%. PE accounted for 58.20% of cases, 10.90% for deep vein thrombosis (DVT), and 30.90% for their association. The mean age of patients was 55.56 years ± 15.52 years. The majority of patients, 90%, were under 66 years of age. The predominance was female, 56%. In lower extremity DVT, calf pain and Homans' sign were present in 56% and 24% of patients. In pulmonary embolism, dyspnea and chest pain were present in 85.50% and 65.50% of patients. Etiological factors were dominated by neoplasia in 10.90%, contraception 5.45% and orthopedic surgery in 5.45% of cases. Cardiovascular risk factors were a sedentary lifestyle (50.90%), obesity (34.45%), high blood pressure (36.36%) and diabetes (21.81%). Laboratory abnormalities were elevation of troponin (46.87%), BNP (40.62%), D-Dimer (62.50%) and anemia (9.09%). Electrocardiographic abnormalities were tachycardia in 65.4% and S1Q3 in 21.81% of patients. Echocardiography showed dilation of the right cavities (47.27%), systolic pulmonary arterial hypertension (38.18%) and thrombus in the right cavitary (5.45%). On thoracic CT angiography, PE was proximal (36.40%), bilateral (61.80%) and massive (29.10%). On venous Doppler ultrasound, TVP was proximal in 65.21%. Conclusion: VETD was more common in women and younger subjects.
    
    VL  - 8
    IS  - 2
    ER  - 

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Author Information
  • Cardiology Department, CHU-Mother Child, Bamako, Mali; Cardiology Department, CHU-Gabriel Touré, Bamako, Mali; Faculty of Medicine, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali

  • Cardiology Department, CHU-Mother Child, Bamako, Mali; Cardiology Department, CHU-Gabriel Touré, Bamako, Mali

  • Cardiology Department, CHU-Mother Child, Bamako, Mali

  • Cardiology Department, CHU-Mother Child, Bamako, Mali

  • Cardiology Department, CHU-Mother Child, Bamako, Mali

  • Cardiology Department, CHU-Mother Child, Bamako, Mali

  • Cardiology Department, CHU-Mother Child, Bamako, Mali

  • Cardiology Department, CHU-Mother Child, Bamako, Mali

  • Cardiology Department, CHU-Mother Child, Bamako, Mali

  • Cardiology Department, CHU-Mother Child, Bamako, Mali

  • Cardiology Department, CHU-Mother Child, Bamako, Mali

  • Cardiology Department, CHU-Mother Child, Bamako, Mali

  • Cardiology Department, CHU-Mother Child, Bamako, Mali

  • Cardiology Department, CHU-Mother Child, Bamako, Mali

  • Faculty of Medicine, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali

  • Faculty of Medicine, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali; Ardiology Department, CHU-Point G, Bamako, Mail

  • Cardiology Department, CHU-Gabriel Touré, Bamako, Mali; Faculty of Medicine, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali