Volume 2, Issue 2, June 2018, Page: 29-48
Benefit Absence of Therapeutic Moderate Hypothermia in the Treatment of Cardiac Arrest: A Systematic Review and Meta-Analysis
García García Miguel Ángel, ICU Department, Hospital de Sagunto, Valencia, Spain
Rosero Arenas María de los Ángeles, Primary Care Center, Cheste, Valencia, Spain
Pérez Lluna Leticia, Internal Medicine Department, Hospital de Sagunto, Valencia, Spain
Martínez Cornejo Alfonso, ICU Department, Hospital de Sagunto, Valencia, Spain
Arizo León David, ICU Department, Hospital de Sagunto, Valencia, Spain
Received: Aug. 10, 2018;       Accepted: Aug. 30, 2018;       Published: Sep. 25, 2018
DOI: 10.11648/j.ccr.20180202.13      View  904      Downloads  44
Abstract
Background: Hyperthermia is frequent after cardiac arrest, and is associated with poor vital and neurological prognosis. In the last few years there have been published some studies that show benefits with moderate hypothermia in these patients, and other studies haven´t shown such benefits. Aim: To collect all clinical trials evaluating the utility of moderate therapeutic hypothermia in survivors of a cardiac arrest. Method: A comprehensive search of clinical trials evaluating moderate hypothermia in patients who survive a cardiac arrest was carried out. The mortality and quality of life of the survivors were evaluated. The quality of the included studies, the publication bias and the heterogeneity of the results were evaluated. Results: there is no significant reduction in mortality (RR 0.97, 95% CI 0.93-1.01) or increase in quality of life (RR 1.07, 95% CI 0.94-1.21) of the patients undergoing moderate hypothermia versus those not treated with that. There are no different results in patients with cardiac arrest with defibrillable and non – defibrillable rhythms, with the different used cooling methods, or even with the induction of intra – cardiac arrest hypothermia. The mortality of these patients is high, and there are no significant differences in relation to the age or sex of them. Conclusion: In patients who survive a cardiac arrest, the induction of moderate hypothermia is not recommended.
Keywords
Therapeutic Hypothermia, Cardiac Arrest, Mortality, Survival with Good Neurological Prognosis
To cite this article
García García Miguel Ángel, Rosero Arenas María de los Ángeles, Pérez Lluna Leticia, Martínez Cornejo Alfonso, Arizo León David, Benefit Absence of Therapeutic Moderate Hypothermia in the Treatment of Cardiac Arrest: A Systematic Review and Meta-Analysis, Cardiology and Cardiovascular Research. Vol. 2, No. 2, 2018, pp. 29-48. doi: 10.11648/j.ccr.20180202.13
Copyright
Copyright © 2018 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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