Volume 3, Issue 4, December 2019, Page: 104-113
Tissue Doppler Imaging Assessment of Left Ventricular Function in Diabetic Patients with Hepatitis C Virus (HCV)
Mohamed Abd El Raheem El Tnoby, Cardiology Department, kafr El Sheikh Hospital, Kafr El Sheikh, Egypt
Ahmed Abdallah Mostafa, Cardiology Department, Police Academy Center, Cairo, Egypt
Waleed Abdo Ebraheem, Cardiology Department, Faculty of Medicine, Menofia University, Menofia, Egypt
Abdallah Mostafa Kamal, Cardiology Department, Faculty of Medicine, Menofia University, Menofia, Egypt
Received: Nov. 25, 2019;       Accepted: Dec. 9, 2019;       Published: Dec. 24, 2019
DOI: 10.11648/j.ccr.20190304.16      View  41      Downloads  30
Abstract
Background & Purpose: Hepatitis C virus (HCV) is the motive of many distinctive kinds of heart illnesses globally. Up till now, few cardiologists are aware of (HCV) as an etiology of heart sickness and its treatment. It has been nicely documented that the presence of diabetes mellitus (DM) changed into carefully connected to cardiovascular disorder. The aim of this work was to evaluate the left ventricular function in diabetic patient with hepatitis C (HCV) using tissue Doppler imaging “TDI”. Study design: Comparative study. Setting: Menofia hospitals, Police Academic Hospital and Kafr El-Sheikh hospital from October 2016 to November 2018. Subjects: We included 50 adult HCV patients, allocated into 2 groups with BMI, age and sex matching. Group A: 25 patients below 50 years old who were diabetic (DM), and infected with HCV. Group B: 25 patients below 50 years old with HCV without Dm. Methods: All patients were subjected to Echocardiographic analysis, Doppler tissue imaging, ECG, blood sugar investigations and PCR for HCV. Results: In the studied population, we found that, comparative study between the 2 groups revealed; significant increase in LA mass index, in DM & HCV group (p = 0.035). Non-significant difference as regards all the remaining Echocardiographic variables (p > 0.05). Regarding correlations among DM & HCV cases; Mitral E had a highly significant positive correlation with HCV-PCR (p < 0.01). E/E' ratio and isovolumic relaxation time had a significant positive correlation with HCV-PCR (p < 0.05 respectively). It also shows that; septal mitral E' had a highly significant negative correlation with HCV-PCR (p = 0.004). And also shows that; the remaining Tissue Doppler Echocardiographic parameters, had non-significant correlation with HCV-PCR (p > 0.05). Conclusion: To conclude, our data suggests that, HCV infection had a significant impact on Lt ventricular diastolic function without any other predisposing factors probably due chronic inflammatory reaction and mild fibrosis of the heart muscle, previous studies did not follow strict inclusion and exclusion criteria that confirm the independence role of (HCV) infection to cause diastolic dysfunction. also, the presence of DM in addition to HCV infection add no more adverse effect on cardiovascular outcomes.
Keywords
Tissue Doppler Imaging, Left Ventricular Function, DM, HCV
To cite this article
Mohamed Abd El Raheem El Tnoby, Ahmed Abdallah Mostafa, Waleed Abdo Ebraheem, Abdallah Mostafa Kamal, Tissue Doppler Imaging Assessment of Left Ventricular Function in Diabetic Patients with Hepatitis C Virus (HCV), Cardiology and Cardiovascular Research. Vol. 3, No. 4, 2019, pp. 104-113. doi: 10.11648/j.ccr.20190304.16
Copyright
Copyright © 2019 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Reference
[1]
Deuffic-Burban, S.; Mohamed, M. K.; Larouze, B.; Carrat, F.; Valleron, A.-J. Expected Increase in Hepatitis C-Related Mortality in Egypt Due to Pre-2000 Infections. Journal of hepatology 2006, 44 (3), 455–461.
[2]
Matsumori, A.; Shimada, T.; Chapman, N. M.; Tracy, S. M.; Mason, J. W. Myocarditis and Heart Failure Associated with Hepatitis C Virus Infection. Journal of cardiac failure 2006, 12 (4), 293–298.
[3]
Raedle-Hurst, T. M.; Welsch, C.; Forestier, N.; Kronenberger, B.; Hess, G.; Herrmann, E.; Zeuzem, S.; Raedle, J. Validity of N-Terminal Propeptide of the Brain Natriuretic Peptide in Predicting Left Ventricular Diastolic Dysfunction Diagnosed by Tissue Doppler Imaging in Patients with Chronic Liver Disease. European journal of gastroenterology & hepatology 2008, 20 (9), 865–873.
[4]
Henriksen, J. H.; Møller, S. Cardiac and Systemic Haemodynamic Complications of Liver Cirrhosis. Scandinavian Cardiovascular Journal 2009, 43 (4), 218–225.
[5]
Kannel, W. B.; McGee, D. L. Diabetes and Glucose Tolerance as Risk Factors for Cardiovascular Disease: The Framingham Study. Diabetes care 1979, 2 (2), 120–126.
[6]
Devereux, R. B.; Roman, M. J.; Paranicas, M.; O’Grady, M. J.; Lee, E. T.; Welty, T. K.; Fabsitz, R. R.; Robbins, D.; Rhoades, E. R.; Howard, B. V. Impact of Diabetes on Cardiac Structure and Function: The Strong Heart Study. Circulation 2000, 101 (19), 2271–2276.
[7]
Lundberg, V.; Stegmayr, B.; Asplund, K.; Eliasson, M.; Huhtasaari, F. Diabetes as a Risk Factor for Myocardial Infarction: Population and Gender Perspectives. Journal of internal medicine 1997, 241 (6), 485–492.
[8]
Ledet, T.; Neubauer, B.; Christensen, N. J.; Lundbaek, K. Diabetic Cardiopathy. Diabetologia 1979, 16 (4), 207–209.
[9]
Fisher, B. M.; Gillen, G.; Lindop, G. B. M.; Dargie, H. J.; Frier, B. M. Cardiac Function and Coronary Arteriography in Asymptomatic Type 1 (Insulin-Dependent) Diabetic Patients: Evidence for a Specific Diabetic Heart Disease. Diabetologia 1986, 29 (10), 706–712.
[10]
Nazar, A.; Guevara, M.; Sitges, M.; Terra, C.; Solà, E.; Guigou, C.; Arroyo, V.; Ginès, P. LEFT Ventricular Function Assessed by Echocardiography in Cirrhosis: Relationship to Systemic Hemodynamics and Renal Dysfunction. Journal of hepatology 2013, 58 (1), 51–57.
[11]
Bender, S. B. Linking Coronary Microvascular and Cardiac Diastolic Dysfunction in Diabetes: Are Women More Vulnerable? Diabetes 2019, 68 (3), 474–475.
[12]
Haas, A. V.; Rosner, B. A.; Kwong, R. Y.; Rao, A. D.; Garg, R.; Di Carli, M. F.; Adler, G. K. Sex Differences in Coronary Microvascular Function in Individuals with Type 2 Diabetes. Diabetes 2019, 68 (3), 631–636.
[13]
Huynh, T.; Harty, B. J.; Claggett, B.; Fleg, J. L.; McKinlay, S. M.; Anand, I. S.; Lewis, E. F.; Joseph, J.; Desai, A. S.; Sweitzer, N. K. Comparison of Outcomes in Patients with Diabetes Mellitus Treated with versus without Insulin+ Heart Failure with Preserved Left Ventricular Ejection Fraction (from the TOPCAT Study). The American journal of cardiology 2019, 123 (4), 611–617.
[14]
Onoue, K.; Saito, Y. Hepatitis C Virus and Cardiovascular Disease. Circulation Journal 2018, CJ–18.
[15]
Pritchett, A. M.; Mahoney, D. W.; Jacobsen, S. J.; Rodeheffer, R. J.; Karon, B. L.; Redfield, M. M. Diastolic Dysfunction and Left Atrial Volume: A Population-Based Study. Journal of the American College of Cardiology 2005, 45 (1), 87–92.
[16]
Teo, S. G.; Yang, H.; Chai, P.; Yeo, T. C. Impact of Left Ventricular Diastolic Dysfunction on Left Atrial Volume and Function: A Volumetric Analysis. European Journal of Echocardiography 2009, 11 (1), 38–43.
[17]
Chew, K. W.; Liu, C.-Y.; Ambale-Venkatesh, B.; Liao, D.; Horwich, T. B.; Lima, J. A.; Bluemke, D. A.; Paul Finn, J.; Butt, A. A.; Currier, J. S. Subclinical Myocardial Disease by Cardiac Magnetic Resonance Imaging and Spectroscopy in Healthy HIV/Hepatitis C Virus-Coinfected Persons. Journal of International Medical Research 2017, 45 (6), 1693–1707.
[18]
Saleh, A.; Matsumori, A.; Negm, H.; Fouad, H.; Onsy, A.; Shalaby, M.; Hamdy, E. Assessment of Cardiac Involvement of Hepatitis C Virus; Tissue Doppler Imaging and NTproBNP Study. Journal of the Saudi Heart Association 2011, 23 (4), 217–223.
[19]
Younossi, Z. M.; Stepanova, M.; Nader, F.; Younossi, Z.; Elsheikh, E. Associations of Chronic Hepatitis C with Metabolic and Cardiac Outcomes. Alimentary pharmacology & therapeutics 2013, 37 (6), 647–652.
[20]
Konno, R.; Tatebe, S.; Sugimura, K.; Satoh, K.; Aoki, T.; Miura, M.; Yamamoto, S.; Sato, H.; Kozu, K.; Terui, Y. Effects of Hepatitis C Virus Antibody-Positivity on Cardiac Function and Long-Term Prognosis in Patients With Adult Congenital Heart Disease. The American journal of cardiology 2018, 122 (11), 1965–1971.
[21]
Petta, S.; Maida, M.; Macaluso, F. S.; Barbara, M.; Licata, A.; Craxì, A.; Cammà, C. Hepatitis C Virus Infection Is Associated with Increased Cardiovascular Mortality: A Meta-Analysis of Observational Studies. Gastroenterology 2016, 150 (1), 145–155.
[22]
Huang, C. H.; Wu, L. S.; Jeng, W. J.; Cheng, Y. F.; Ko, Y. S.; Sheen, I. S.; Lin, C. Y. In HCV-Related Liver Cirrhosis, Local Pulse Wave Velocity Increases and in Decompensated Patients Correlates with Poorer Survival. Plo S one 2019, 14 (3), e0212770.
[23]
Tsui, J. I.; Whooley, M. A.; Monto, A.; Seal, K.; Tien, P. C.; Shlipak, M. Association of Hepatitis C Virus Seropositivity with Inflammatory Markers and Heart Failure in Persons with Coronary Heart Disease: Data from the Heart and Soul Study. Journal of cardiac failure 2009, 15 (5), 451–456.
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